Translational Biomarker Analytical Core

The Translational Biomarker Analytical Core (TBAC) makes available to Diabetes Research Center investigators a variety of high quality radioimmunoassay and other analyses that are critical to basic, translational and clinical investigators studying diabetes mellitus, insulin resistance, insulin and C-peptide secretion, glucagon dynamics, energy homeostasis, and complications of diabetes. The services provided are best based in a centralized core laboratory because they require special instrumentation and methods that are difficult or impracticably expensive to establish in the laboratories of individual members of the research base. This arrangement also allows for coordinated consultations and improved reliability and reproducibility of the various assays employed. In addition to high quality radio-immunoassay, ELISA, and other analytical methods, TBAC facilitates access to the measurement of small molecules by targeted metabolomics/lipidomics at the Irving Institute’s Metabolomics Core.

F. Xavier Pi-Sunyer, MD
Core Director
fxp1@columbia.edu

Blandine Laferrère, MD
Core Co-Director
bbl14@cumc.columbia.edu
(212) 851-5562

Reservations and Prices

Please fill out the request form and email to pz24@cumc.columbia.edu to obtain a quote.

Services

  1. Consulting services for study design, sample processing, assay methods for diabetes clinical investigators
  2. Large variety of RIAs: GLP-1, PYY, oxyntomodulin, ghrelin, C-peptide, insulin, pro-insulin, glucagon, leptin, adiponectin, etc...
  3. Large variety of ELISA: GLP-1 total and active, GIP, acetaminophen, orexin, cortisol, Substance amyloid A, cytokines, etc..
  4. Lipids, glucose, glycerol, FFA, nitrogen as well as bomb calorimetry analysis
  5. Rapid 1-2 months turnover for most assays
  6. Assays can be developed on demand, based on investigator needs

Full list of TBAC services

RIA

  • Adiponectin
  • Cholecystokinin
  • Cortisol
  • C-peptide
  • DHEA
  • Estradiol
  • FSH
  • Total ghrelin
  • Total GLP-1
  • Glucagon
  • hCG
  • Insulin
  • Leptin
  • LH
  • Osteocalcin
  • Progesterone
  • Proinsulin
  • Prolactin
  • PYY total and PYY3-36
  • Resistin
  • T3
  • Testosterone

ELISA

  • Amylin
  • Beta-OH butyrate
  • CRP
  • IL6
  • IL8
  • Insulin
  • GIP
  • GLP-1
  • Proinsulin
  • Insulin
  • Leptin
  • Nandrolone
  • NTX
  • PAI-1
  • TNF-a
  • TPA

Enzymatic

  • Acetaminophen
  • DNA extraction
  • Deuterated glucose
  • FFA
  • Glucose
  • Glycerol
  • Lactate
  • Lipids (cholesterol total, LDL, HDL, triglyceride)
  • Tissue lipid content
  • Triglyceride synthesis

HLPC

  • Catecholamines: dopamine, epinephrine, norepinephrine

Spectrophotometry

  • D-xylose

Quintron Analyzer

  • H2 and methane breath analysis

Bomb Calorimetry

  • Heat, (ash, , lipid, protein)

Targeted Lipidomics

  • Please inquire

Targeted Metabolomics

  • Please inquire

Personnel

  • Ping Zhou

    Core Technologist

    • (212) 342-6905
  • Renu Nandakumar

    Metabolomic/Lipidomic Analysis

  • Hongfeng Jiang

    Metabolomic/Lipidomic Analysis

Translational Biomarker Analytical Core
650 W 168th St
William Black Medical Research Building (BB-20)
New York, NY 10032
United States