Visualization of pSTAT3 in the Hypothalamus of High Fat-fed Mice
Morabito report in PlosONE
Morabito report in PlosONE on the effect of diet-induced neuronal responses to leptin and their role in the persistence of a metabolic defense to acquired body weight changes. They showed that the effects of diet on leptin signaling varied by brain region, and that high-fat diet attenuates leptin signaling throughout the brain, but some brain regions maintain their ability to sense leptin. Weight loss restores leptin sensing to some degree in most brain regions, while other brain regions display hypersensitivity to leptin following weight loss.