Ozcan and Tabas on Calcium Signaling and ER Stress in Insulin Resistance and Atherosclerosis

January 1, 2017

Endoplasmic reticulum (ER) stress response pathways. Perturbations in ER homoeostasis activate three ER membrane localized proteins: IRE1, ATF6 and PERK. These ER stress transducers lower ER load through regulating several transcription factors such as XBP1s, p58IPK and CHOP. PERK, protein kinase RNA-like ER kinase; IRE1, inositol requiring protein-1; ATF6, activating transcription factor 6; RIDD, regulated IRE1-dependent decay; JNK, c-Jun N-terminal kinase; XBP1, X-box-binding protein-1; p58IPK, double-stranded RNA-activated protein kinase inhibitor; p-eIF2α, phosphorylated-eukaryotic translation initiation factor 2α; ATF4, activating transcription factor 4; CHOP, C/EBP homolog protein; ERO-1α, ER oxidase-1α; IP3R, inositol triphosphate receptor; CaMKII; calcium/calmodulin-dependent protein kinase II; Trb3, Tribbles homolog 3.

Read the article: Calcium signalling and ER stress in insulin resistance and atherosclerosis.