DRC’s Dr. Remi Creusot is the Recipient of a New NIH R21 Grant

Tolerance-inducing properties of human dendritic cell subsets in vivo

Friday, January 16, 2015 - Tuesday, March 3, 2015

Dr. Remi Creusot
Dr. Remi Creusot

DRC’s Dr. Remi Creusot is the recipient of a new NIH R21 grant titled "Tolerance-inducing properties of human dendritic cell subsets in vivo." This highly competitive grant is awarded for high-risk/high benefit research. The objective of the funded project is to develop a a mouse harboring a human immune system to study autoimmune diseases such as Type 1 diabetes.

The objective of the funded project is to develop a humanized mouse model (a mouse harboring a human immune system) to study the ability of several human antigen-presenting cells to mediate immune tolerance in an in vivo environment. Antigen-presenting cells program T lymphocytes to either react against antigens if they are non-self (from pathogens for examples) or to not react if these are self-antigens. By better understand these cells, we will be able to exploit them therapeutically to treat autoimmune diseases such as Type 1 diabetes.